We are
a collaborative lab that works at the intersection of cancer genomics, disparities, and molecular biology.
working to understand the molecular mechanisms that make cancer cells immortal.
focused on improving cancer health equity and ensuring that minority populations are included in genomics studies.
2022
The 5-Hydroxymethylcytosine Landscape of Prostate Cancer
Sjöström M, Zhao SG, Levy S, Zhang M, Ning Y, Shrestha R, Lundberg A, Herberts C, Foye A, Aggarwal R, Hua JT, Li H, Bergamaschi A, Maurice-Dror C, Maheshwari A, Chen S, Ng SWS, Ye W, Petricca J, Fraser M, Chesner L, Perry MD, Moreno-Rodriguez T, Chen WS, Alumkal JJ, Chou J, Morgans AK, Beer TM, Thomas GV, Gleave M, Lloyd P, Phillips T, McCarthy E, Haffner MC, Zoubeidi A, Annala M, Reiter RE, Rettig MB, Witte ON, Fong L, Bose R, Huang FW, Luo J, Bjartell A, Lang JM, Mahajan NP, Lara PN, Evans CP, Tran PT, Posadas EM, He C, Cui XL, Huang J, Zwart W, Gilbert LA, Maher CA, Boutros PC, Chi KN, Ashworth A, Small EJ, He HH, Wyatt AW, Quigley DA, Feng FY. Cancer Res. 2022 Oct 17:OF1-OF15. doi: 10.1158/0008-5472.CAN-22-1123. Epub ahead of print. PMID: 36251389.
Song H, Bucher S, Rosenberg K, Tsui M, Burhan D, Hoffman D, Cho SJ, Rangaswami A, Breese M, Leung S, Ventura MVP, Sweet-Cordero EA, Huang FW, Nijagal A, Wang B. Nat Commun. 2022 Aug 25;13(1):4878.
The Impact of Androgen Deprivation Therapy on COVID-19 Illness in Men With Prostate Cancer
Shah NJ, Patel VG, Zhong X, Pina L, Hawley JE, Lin E, Gartrell BA, Febles VA, Wise DR, Qin Q, Mellgard G, Joshi H, Nauseef JT, Green DA, Vlachostergios PJ, Kwon DH, Huang FW, Liaw B, Tagawa S, Kantoff P, Morris MJ, Oh WK. JNCI Cancer Spectr. 2022 May 2;6(3):pkac035.
The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans
Tabula Sapiens Consortium. Science. 2022 May 13;376(6594):eabl4896.
Deconstructing, Addressing, and Eliminating Racial and Ethnic Inequities in Prostate Cancer Care
Nyame YA, Cooperberg MR, Cumberbatch MG, Eggener SE, Etzioni R, Gomez SL, Haiman C, Huang FW, Lee CT, Litwin MS, Lyratzopoulos G, Mohler JL, Murphy AB, Pettaway C, Powell IJ, Sasieni P, Schaeffer EM, Shariat SF, Gore JL. Eur Urol. 2022 Mar 30:S0302-2838(22)01677-3.
Kwon DH, Cadena J, Nguyen S, Chan KHR, Soper B, Gryshuk AL, Hong JC, Ray P, Huang FW. Cancer Med. 2022 Jun;11(11):2204-2215.
Cell types of origin of the cell-free transcriptome
Vorperian SK, Moufarrej MN; Tabula Sapiens Consortium, Quake SR. Nat Biotechnol. 2022 Jun;40(6):855-861.
Mutations in JAK/STAT and NOTCH1 Genes Are Enriched in Post-Transplant Lymphoproliferative Disorders
Butzmann A, Sridhar K, Jangam D, Song H, Singh A, Kumar J, Chisholm KM, Pinsky B, Huang FW, Ohgami RS. Front Oncol. 2022 Jan 17;11:790481.
Stover EH, Oh C, Keskula P, Choudhury AD, Tseng YY, Adalsteinsson VA, Lohr JG, Thorner AR, Ducar M, Kryukov GV, Ha G, Rosenberg M, Freeman SS, Zhang Z, Wu X, Van Allen EM, Takeda DY, Loda M, Wu CL, Taplin ME, Garraway LA, Boehm JS, Huang FW. Prostate. 2022 Apr;82(5):584-597.
Song, H, Weinstein, HNW, Allegakoen P, Wadsworth MH, Xie J, Yang H, Castro EA, Lu KL, Stohr BA, Feng FY, Carroll PR, Wang B, Cooperberg MR, Shalek AK, Huang FW. Nat Commun. 2022 Jan 10;13(1):141.
2021
Tumor Mutations Across Racial Groups in a Real-World Data Registry
Kamran SC, Xie J, Cheung ATM, Mavura MY, Song H, Palapattu EL, Madej J, Gusev A, Van Allen EM, Huang FW. JCO Precis Oncol. 2021 Nov;5:1654-1658.
Implementing Patient-Directed Cancer Education Materials Across Nigeria
Dickerson JC, Ibeka P, Inoyo I, Oke OO, Adewuyi SA, Barry D, Bello A, Fasawe O, Garrity P, Habeebu M, Huang FW, Mulema V, Nwankwo KC, Remen D, Wiwa O, Bhatt AS, Roy M. JCO Glob Oncol. 2021 Sep;7:1610-1619.
Swami N, Hwang WL, Guo JA, Hoffman H, Abramowitz MC, Elbakouny Z, Beltran H, Chipidza F, Choueiri T, Pra AD, Huang FW, Kaochar S, Kantoff P, Kim DW, Kishan AU, Kobetz E, Marinac C, Mucci LA, Muralidhar V, Pollack A, Sanford NN, Schaeffer EM, Spratt DE, Zhao SG, Rebbeck TR, Nguyen PL, Feng FY, Mahal BA, Alshalalfa M. Cancer Genet. 2021 Nov;258-259:61-68.
RNA splicing programs define tissue compartments and cell types at single-cell resolution
Olivieri JE, Dehghannasiri R, Wang PL, Jang S, de Morree A, Tan SY, Ming J, Ruohao Wu A; Tabula Sapiens Consortium, Quake SR, Krasnow MA, Salzman J. Elife. 2021 Sep 13;10:e70692.
Integrated evaluation of telomerase activation and telomere maintenance across cancer cell lines
Hu K, Ghandi M, Huang FW. Elife. 2021 Sep 6;10:e66198.
Chen CL, Huang FW, Huang SS, Huang JS. FASEB Bioadv. 2021 Jun 16;3(9):709-729.
How Cancer Risk SNPs May Contribute to Prostate Cancer Disparities
Mavura MY, Huang FW. Cancer Res. 2021 Jul 15;81(14):3764-3765.
Cannon-Albright LA, Teerlink CC, Stevens J, Huang FW, Sipeky C, Schleutker J, Hernandez R, Facelli J, Agarwal N, Trump DL.Cancers (Basel). 2021 May 15;13(10):2399.
de Kouchkovsky I, Zhang L, Philip EJ, Wright F, Kim DM, Natesan D, Kwon D, Ho H, Ho S, Chan E, Porten SP, Wong AC, Desai A, Huang FW, Chou J, Oh DY, Pruthi RS, Fong L, Small EJ, Friedlander TW, Koshkin VS. J Immunother Cancer. 2021 May;9(5):e002127.
Evaluating the transcriptional fidelity of cancer models.
Peng D, Gleyzer R, Tai WH, Kumar P, Bian Q, Isaacs B, da Rocha EL, Cai S, DiNapoli K, Huang FW, Cahan P. Genome Med. 2021 Apr 29;13(1):73.
McKay RR, Gold T, Zarif JC, Chowdhury-Paulino IM, Friedant A, Gerke T, Grant M, Hawthorne K, Heath E, Huang FW, Jackson MD, Mahal B, Ogbeide O, Paich K, Ragin C, Rencsok EM, Simmons S, Yates C, Vinson J, Kantoff PW, George DJ, Mucci LA.JCO Glob Oncol. 2021 Apr;7:495-505.
Global Precision Oncology: A Call to Action on Expanding Access to Targeted Cancer Therapies.
Bharadwaj M, Vallurupalli M, Huang FW. Oncologist. 2021 May;26(5):353-355.
Gomez SL, Washington SL 3rd, Cheng I, Huang FW, Cooperberg MR. Eur Urol. 2021 Jan;79(1):42-43.
2020
The DNA methylation landscape of advanced prostate cancer.
Zhao SG, Chen WS, Li H, Foye A, Zhang M, Sjöström M, Aggarwal R, Playdle D, Liao A, Alumkal JJ, Das R, Chou J, Hua JT, Barnard TJ, Bailey AM, Chow ED, Perry MD, Dang HX, Yang R, Moussavi-Baygi R, Zhang L, Alshalalfa M, Laura Chang S, Houlahan KE, Shiah YJ, Beer TM, Thomas G, Chi KN, Gleave M, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Yvonne Kim M, Fong L, Spratt DE, Morgan TM, Bose R, Huang FW, Li H, Chesner L, Shenoy T, Goodarzi H, Asangani IA, Sandhu S, Lang JM, Mahajan NP, Lara PN, Evans CP, Febbo P, Batzoglou S, Knudsen KE, He HH, Huang J, Zwart W, Costello JF, Luo J, Tomlins SA, Wyatt AW, Dehm SM, Ashworth A, Gilbert LA, Boutros PC, Farh K, Chinnaiyan AM, Maher CA, Small EJ, Quigley DA, Feng FY.
Nat Genet. 2020 Aug;52(8):778-789. doi: 10.1038/s41588-020-0648-8. Epub 2020 Jul 13. View on Pubmed.
Genomic Profiling of Prostate Cancers from Men with African and European Ancestry.
Koga Y, Song H, Chalmers ZR, Newberg J, Kim E, Carrot-Zhang J, Piou D, Polak P, Abdulkadir SA, Ziv E, Meyerson M, Frampton GM, Campbell JD, Huang FW.
Clin Cancer Res. 2020 Jul 10. View on Pubmed.
Diversity of Enrollment in Prostate Cancer Clinical Trials: Current Status and Future Directions.
Rencsok EM, Bazzi LA, McKay RR, Huang FW, Friedant A, Vinson J, Peisch S, Zarif JC, Simmons S, Hawthorne K, Villanti P, Kantoff PW, Heath E, George DJ, Mucci LA. Cancer Epidemiol Biomarkers Prev. 2020 Jul;29(7):1374-1380. View on PubMed.
Expression of ACE2, the SARS-CoV-2 Receptor, and TMPRSS2 in Prostate Epithelial Cells. Song H, Seddighzadeh B, Cooperberg MR, Huang FW. . Eur Urol. 2020 May 06. View on PubMed. PDF: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263499/pdf/nihpp-2020.04.24.056259.pdf
Assessing and Addressing the Need for Cancer Patient Education in a Resource-Limited Setting in Haiti. Schleimer LE, Desameau PG, Damuse R, Olsen M, Manzo V, Cardenas C, Mehrtash H, Krakauer EL, Masamba L, Wang C, Bhatt AS, Shulman LN, Huang FW. Oncologist. 2020 Apr 25. View on PubMed
Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers. Stern JL, Hibshman G, Hu K, Ferrara SE, Costello JC, Kim W, Tamayo P, Cech TR, Huang FW. Telomerase Promoter Mutations in Multiple Cancers. Mol Cancer Res. 2020 Apr 10. View on PubMed
De novo somatic mutations and KRAS amplification are associated with cholangiocarcinoma in a patient with a history of choledochal cyst. Schwab ME, Song H, Mattis A, Phelps A, Vu LT, Huang FW, Nijagal A.J Pediatr Surg. 2020 Mar 24. View on PubMed
2019
Correction: The long tail of oncogenic drivers in prostate cancer. Armenia J, Wankowicz SAM, Liu D, Gao J, Kundra R, Reznik E, Chatila WK, Chakravarty D, Han GC, Coleman I, Montgomery B, Pritchard C, Morrissey C, Barbieri CE, Beltran H, Sboner A, Zafeiriou Z, Miranda S, Bielski CM, Penson AV, Tolonen C, Huang FW, Robinson D, Wu YM, Lonigro R, Garraway LA, Demichelis F, Kantoff PW, Taplin ME, Abida W, Taylor BS, Scher HI, Nelson PS, de Bono JS, Rubin MA, Sawyers CL, Chinnaiyan AM, Schultz N, Van Allen EM. Publisher Nat Genet. 2019 Jul; 51(7):1194. View on PubMed
Next-generation characterization of the Cancer Cell Line Encyclopedia. Ghandi M, Huang FW, Jané-Valbuena J, Kryukov GV, Lo CC, McDonald ER, Barretina J, Gelfand ET, Bielski CM, Li H, Hu K, Andreev-Drakhlin AY, Kim J, Hess JM, Haas BJ, Aguet F, Weir BA, Rothberg MV, Paolella BR, Lawrence MS, Akbani R, Lu Y, Tiv HL, Gokhale PC, de Weck A, Mansour AA, Oh C, Shih J, Hadi K, Rosen Y, Bistline J, Venkatesan K, Reddy A, Sonkin D, Liu M, Lehar J, Korn JM, Porter DA, Jones MD, Golji J, Caponigro G, Taylor JE, Dunning CM, Creech AL, Warren AC, McFarland JM, Zamanighomi M, Kauffmann A, Stransky N, Imielinski M, Maruvka YE, Cherniack AD, Tsherniak A, Vazquez F, Jaffe JD, Lane AA, Weinstock DM, Johannessen CM, Morrissey MP, Stegmeier F, Schlegel R, Hahn WC, Getz G, Mills GB, Boehm JS, Golub TR, Garraway LA, Sellers WR. Nature. 2019 05; 569(7757):503-508. View on PubMed
Racial Disparities in Low-Risk Prostate Cancer-Reply. Mahal BA, Huang FW. JAMA. 2019 05 07; 321(17):1727-1728. View on PubMed
A Tumor-Agnostic NTRK (TRK) Inhibitor. Huang FW, Feng FY. Cell. 2019 03 21; 177(1):8. View on PubMed
Prostate Cancer Genomic-risk Differences Between African-American and White Men Across Gleason Scores. Mahal BA, Alshalalfa M, Spratt DE, Davicioni E, Zhao SG, Feng FY, Rebbeck TR, Nguyen PL, Huang FW. Eur Urol. 2019 Jun; 75(6):1038-1040. View on PubMed
2018
Prostate Cancer-Specific Mortality Across Gleason Scores in Black vs Nonblack Men. Mahal BA, Berman RA, Taplin ME, Huang FW. JAMA. 2018 12 18; 320(23):2479-2481. View on PubMed
Towards Greater Inclusion in Cancer Genomics Studies. Cancer Res. Huang FW. 2018 12 15; 78(24):6726-6727. View on PubMed
The long tail of oncogenic drivers in prostate cancer. Armenia J, Wankowicz SAM, Liu D, Gao J, Kundra R, Reznik E, Chatila WK, Chakravarty D, Han GC, Coleman I, Montgomery B, Pritchard C, Morrissey C, Barbieri CE, Beltran H, Sboner A, Zafeiriou Z, Miranda S, Bielski CM, Penson AV, Tolonen C, Huang FW, Robinson D, Wu YM, Lonigro R, Garraway LA, Demichelis F, Kantoff PW, Taplin ME, Abida W, Taylor BS, Scher HI, Nelson PS, de Bono JS, Rubin MA, Sawyers CL, Chinnaiyan AM, Schultz N, Van Allen EM. Nat Genet. 2018 05; 50(5):645-651. View on PubMed
2017
Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes. Stern JL, Paucek RD, Huang FW, Ghandi M, Nwumeh R, Costello JC, Cech TR. Cell Rep. 2017 12 26; 21(13):3700-3707. View on PubMed
Identification of novel prostate cancer drivers using RegNetDriver: a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network. Dhingra P, Martinez-Fundichely A, Berger A, Huang FW, Forbes AN, Liu EM, Liu D, Sboner A, Tamayo P, Rickman DS, Rubin MA, Khurana E. Genome Biol. 2017 07 27; 18(1):141. View on PubMed
Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function ERF Mutations. Huang FW, Mosquera JM, Garofalo A, Oh C, Baco M, Amin-Mansour A, Rabasha B, Bahl S, Mullane SA, Robinson BD, Aldubayan S, Khani F, Karir B, Kim E, Chimene-Weiss J, Hofree M, Romanel A, Osborne JR, Kim JW, Azabdaftari G, Woloszynska-Read A, Sfanos K, De Marzo AM, Demichelis F, Gabriel S, Van Allen EM, Mesirov J, Tamayo P, Rubin MA, Powell IJ, Garraway LA. Cancer Discov. 2017 09; 7(9):973-983. View on PubMed
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden. Chalmers ZR, Connelly CF, Fabrizio D, Gay L, Ali SM, Ennis R, Schrock A, Campbell B, Shlien A, Chmielecki J, Huang F, He Y, Sun J, Tabori U, Kennedy M, Lieber DS, Roels S, White J, Otto GA, Ross JS, Garraway L, Miller VA, Stephens PJ, Frampton GM. Genome Med. 2017 04 19; 9(1):34. View on PubMed
2016
DMSO Enhances TGF-ß Activity by Recruiting the Type II TGF-ß Receptor From Intracellular Vesicles to the Plasma Membrane. Huang SS, Chen CL, Huang FW, Hou WH, Huang JS. J Cell Biochem. 2016 07; 117(7):1568-79. View on PubMed
Awareness, Interest, and Preferences of Primary Care Providers in Using Point-of-Care Cancer Screening Technology. Kim CS, Vanture S, Cho M, Klapperich CM, Wang C, Huang FW. PLoS One. 2016; 11(1):e0145215. View on PubMed
2015
TERT promoter mutations and monoallelic activation of TERT in cancer. Huang FW, Bielski CM, Rinne ML, Hahn WC, Sellers WR, Stegmeier F, Garraway LA, Kryukov GV. Oncogenesis. 2015 Dec 14; 4:e176. View on PubMed
Rapid Intraoperative Molecular Characterization of Glioma.
Shankar GM, Francis JM, Rinne ML, Ramkissoon SH, Huang FW, Venteicher AS, Akama-Garren EH, Kang YJ, Lelic N, Kim JC, Brown LE, Charbonneau SK, Golby AJ, Sekhar Pedamallu C, Hoang MP, Sullivan RJ, Cherniack AD, Garraway LA, Stemmer-Rachamimov A, Reardon DA, Wen PY, Brastianos PK, Curry WT, Barker FG 2nd, Hahn WC, Nahed BV, Ligon KL, Louis DN, Cahill DP, Meyerson M. JAMA Oncol. 2015 Aug;1(5):662-7. View on Pubmed.
Genomic Classification of Cutaneous Melanoma.
Cancer Genome Atlas Network. Cell. 2015 Jun 18;161(7):1681-96. View on Pubmed.
For all papers: https://pubmed.ncbi.nlm.nih.gov/term=franklin%20huang&timeline=expanded&sort=date&size=20&pos=1